Evopoint Announces Clinical Trial Collaboration Agreement with MSD for the Study of XNW5004 in Combination with KEYTRUDA® (pembrolizumab) in Advanced Solid Tumors

XNW5004 is a rationally designed, highly selective and potent EZH2 inhibitor with potentially best-in-class efficacy and safety profile demonstrated in a Phase I trial in patients with lymphoma. The combination trial is an open label, single-arm Phase Ib/II study designed to establish the RP2D dose of XNW5004 in combination with KEYTRUDA® and to evalsuate the safety and efficacy of XNW5004 in combination with KEYTRUDA® for patients with advanced solid tumors.

“We are extremely pleased to collaborate with MSD,a well-established world leader and pioneer in the field of cancer immunology,”said Jing Qiang, Chairmen of Evopoint. “Our promising drug candidate, XNW5004,has demonstrated a potential additive benefit when given in combination withanti-PD-1 therapy in animal models. Basedon the mechanism of action of EZH2 in tumor cells and tumor microenvironment,the observations in our preclinical studies, and the excellent efficacy andsafety profile of XNW5004 exhibited in the Phase I study, we are veryoptimistic that XNW5004 in combination with KEYTRUDA® may significantly improvethe clinical outcome in patients with advanced solid tumors, potentially providingmeaningful clinical benefits to those patients for improving their lives.”

Under the terms of the agreement, Evopoint willsponsor the Phase Ib/II trial and MSD will supply KEYTRUDA®. Evopoint maintains theglobal rights to XNW5004.

KEYTRUDA® is a registered trademark of Merck Sharp & Dohme LLC, a subsidiaryof Merck & Co., Inc., Rahway, NJ, USA.

AboutXNW5004

XNW5004 is a rationally designed, highly selective and potent small molecule inhibitor of EZH2 with the potential of being the best-in-class EZH2 inhibitor. Studies have revealed that EZH2 play important roles in the pathological processes including tumor igenesis, tumor progression and tumor immunogenicity. Targeting EZH2 has been proven a relatively effective treatment strategy in liquid tumors.

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